The Methylation Cycle that I have focused on in this book describes genetic weaknesses in the particular pathway that is involved in generating and utilizing methyl groups in the body. This central pathway is particularly amenable to nutrigenomic screening for genetic weaknesses. Defects in methylation lay the appropriate groundwork for the further assault of environmental and infectious agents and result in an increased risk for additional health conditions including diabetes, cardiovascular disease, thyroid dysfunction, neurological inflammation, chronic viral infection, neurotransmitter imbalances, atherosclerosis, cancer, aging, neural tube defects, Alzheimer’s disease and autism. As a result of decreased activity in the Methylation Cycle due to mutations, there is a shortage of methyl groups in the body for a variety of important functions. Methyl groups are “CH3″ groups that are moved around in the body to turn on or off genes. There are several particular sites in this pathway where blocks can occur as a result of genetic weaknesses. Supplementation with appropriate foods and nutrients can help bypass these mutations to allow for restored function of the pathway.
“Methylation occurs a billion times a second throughout the body, affecting everything from fetal development to brain function. It regulates the expression of genes. It preserves the fatty membranes that insulate our cells. And it helps regulate the action of various hormones and neurotransmitters, including serotonin, melatonin, dopamine and adrenaline. Without methylation there could be no life as we know it” (Cooney, Methyl Magic).
It has not been my desire to scare you, quite the contrary. My goal is to empower you, to share information so that you have the knowledge and ability to bypass issues in this critical pathway so that you can chart your own personalized Roadmap to health. By this point I would hope that you comprehend that this may be the pathway for a better, healthier existence. Now, it is up to you to change your stars, to chart a new path for your own health as well as the health of your future generations.